Having more than the normal number of proteins is a red flag. But when you have late-stage multiple myeloma, your symptoms may show up as: Being sick to your stomach. Bone pain in your back or Dec 10, 2021 · The adage for smoldering myeloma (SMM) has been to observe without treatment, until criteria for active multiple myeloma were satisfied. Definitions and risk stratification models have become more sophisticated, with prognostication tailored to include high-risk cytogenetics as per the most recent International Myeloma Working Group 2020 risk model. Targeted therapy is usually used to treat multiple myeloma. It uses drugs to target specific molecules (such as proteins) on or inside cancer cells. These molecules help send signals that tell cells to grow or divide. By targeting these molecules, the drugs stop the growth and spread of cancer cells and limit harm to normal cells. Nov 23, 2023 · Usual Adult Dose for Multiple Myeloma IN COMBINATION WITH LENALIDOMIDE AND DEXAMETHASONE: Cycles 1 and 2: 10 mg/kg IV once a week on Days 1, 8, 15, and 22 of a 28-day cycle Dec 19, 2023 · Patients must be diagnosed with asymptomatic high-risk smoldering multiple myeloma (SMM) within the past 12 months. High-risk is defined by any one of the following factors: Abnormal serum free light chain ratio (=< 0.125 or >= 8.0 and involved chain < 100 mg/L) by serum free light chain (FLC) assay This month, Sagar Lonial, MD, addresses a question about duration of maintenance therapy in a patient diagnosed with multiple myeloma. CLINICAL DILEMMA I have a young patient who was diagnosed with IgG lambda multiple myeloma in 1997. .

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